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Sai-Juan Chen Selected Research

Retinoic Acid Receptors (Retinoic Acid Receptor)

8/2013RARα-PLZF oncogene inhibits C/EBPα function in myeloid cells.
2/20138-CPT-cAMP/all-trans retinoic acid targets t(11;17) acute promyelocytic leukemia through enhanced cell differentiation and PLZF/RARα degradation.
6/2011From an old remedy to a magic bullet: molecular mechanisms underlying the therapeutic effects of arsenic in fighting leukemia.

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Sai-Juan Chen Research Topics

Disease

33Neoplasms (Cancer)
10/2021 - 11/2002
33Leukemia
01/2019 - 02/2002
30Acute Promyelocytic Leukemia
01/2021 - 02/2002
15Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
01/2019 - 12/2003
11Lymphoma (Lymphomas)
02/2017 - 10/2006
11BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
08/2012 - 12/2004
9Hematologic Neoplasms (Hematological Malignancy)
01/2021 - 05/2005
4Graves Disease (Basedow Disease)
01/2019 - 08/2011
3Inflammation (Inflammations)
10/2021 - 05/2015
3Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse)
06/2019 - 07/2007
3Genetic Translocation (Chromosomal Translocation)
01/2019 - 11/2002
3Myeloid Leukemia (Leukemia, Myelocytic)
01/2019 - 08/2012
3Myeloproliferative Disorders (Myeloproliferative Disorder)
03/2012 - 02/2008
2Thalassemia
11/2021 - 02/2009
2Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
11/2021 - 01/2021
2Hemorrhage
11/2019 - 04/2018
2Cardiotoxicity
06/2019 - 07/2009
2Multiple Myeloma
01/2019 - 02/2012
2Carcinogenesis
04/2018 - 06/2015
2Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL)
01/2018 - 05/2006
2Lung Neoplasms (Lung Cancer)
06/2015 - 06/2007
2Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
05/2015 - 02/2013
2Hyperthyroidism
08/2013 - 08/2011
2Blast Crisis (Blast Phase)
03/2012 - 05/2006
2Body Weight (Weight, Body)
07/2009 - 04/2007
1Fatigue
11/2021
1Fever (Fevers)
11/2021
1Dizziness (Lightheadedness)
11/2021
1Pharyngitis (Sore Throat)
11/2021
1Exanthema (Rash)
11/2021
1Hemophilia B (Haemophilia B)
10/2021
1Anemia
01/2021
1Myelodysplastic Syndromes (Myelodysplastic Syndrome)
01/2020
1Genomic Instability
04/2018
1Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (Leukemia, Pre B Cell)
01/2017

Drug/Important Bio-Agent (IBA)

21Tretinoin (Retinoic Acid)FDA LinkGeneric
01/2021 - 02/2002
18Proteins (Proteins, Gene)FDA Link
01/2019 - 12/2003
14Arsenic Trioxide (Trisenox)FDA Link
01/2021 - 02/2002
9Pharmaceutical PreparationsIBA
01/2021 - 12/2004
9ArsenicIBA
11/2013 - 01/2005
7Imatinib Mesylate (Gleevec)FDA Link
02/2012 - 12/2004
5DNA (Deoxyribonucleic Acid)IBA
11/2021 - 06/2007
5Transcription Factors (Transcription Factor)IBA
10/2021 - 08/2004
5MethyltransferasesIBA
01/2020 - 02/2010
5Cytarabine (Cytosar-U)FDA LinkGeneric
01/2019 - 01/2005
5Oncogene Proteins (Oncogene Protein)IBA
03/2012 - 12/2004
4Therapeutic UsesIBA
02/2013 - 05/2005
4Retinoic Acid Receptor alphaIBA
03/2008 - 02/2002
3Histones (Histone)IBA
01/2020 - 02/2010
3Lysine (L-Lysine)FDA Link
01/2020 - 02/2010
3Rituximab (Mabthera)FDA Link
02/2017 - 07/2007
3Bortezomib (Velcade)FDA Link
11/2015 - 01/2011
3Biomarkers (Surrogate Marker)IBA
12/2013 - 06/2007
3Retinoic Acid Receptors (Retinoic Acid Receptor)IBA
08/2013 - 06/2011
3Arsenicals (Arsenic Compounds)IBA
04/2012 - 11/2002
3Tyrosine Kinase InhibitorsIBA
02/2012 - 01/2007
3Proteasome InhibitorsIBA
01/2011 - 04/2008
3Biological ProductsIBA
04/2009 - 12/2005
2GlobinsIBA
11/2021 - 02/2009
2RNA (Ribonucleic Acid)IBA
10/2021 - 01/2018
2Chimeric Antigen ReceptorsIBA
01/2021 - 01/2019
2EnzymesIBA
11/2019 - 01/2014
2AnthracyclinesIBA
06/2019 - 01/2019
2Doxorubicin (Adriamycin)FDA LinkGeneric
06/2019 - 06/2011
2Long-Acting Thyroid Stimulator (LATS)IBA
01/2019 - 08/2011
2AntigensIBA
10/2018 - 08/2013
2Phosphoric Monoester Hydrolases (Phosphatases)IBA
01/2017 - 08/2008
2Glucose (Dextrose)FDA LinkGeneric
11/2016 - 09/2014
2DNA Methyltransferase 3AIBA
02/2014 - 01/2013
2alpha-hydroxyglutarateIBA
12/2013 - 10/2013
2realgar-indigo naturalisIBA
11/2013 - 03/2008
2eriocalyxin BIBA
02/2013 - 03/2010
2oridoninIBA
03/2012 - 04/2007
2bcr-abl Fusion ProteinsIBA
03/2012 - 02/2005
2Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
02/2012 - 12/2010
2Monoclonal AntibodiesIBA
06/2011 - 12/2007
2Cell Adhesion Molecule-1IBA
06/2011 - 01/2011
2Phosphotransferases (Kinase)IBA
03/2010 - 01/2007
2Positive Regulatory Domain I-Binding Factor 1IBA
07/2007 - 06/2007
2promyelocytic leukemia-retinoic acid receptor alpha fusion oncoproteinIBA
01/2007 - 11/2002
2Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
01/2007 - 02/2005
2Aligeron (AS 2)IBA
04/2004 - 11/2002
1Thalidomide (Thalomid)FDA Link
11/2021
1Immunoglobulin Heavy Chains (Immunoglobulin Heavy Chain)IBA
11/2021
1Small Cytoplasmic RNAIBA
10/2021
1Blood Coagulation Factors (Coagulation Factor)IBA
10/2021
1Fluorouracil (Carac)FDA LinkGeneric
01/2021
1Cysteine (L-Cysteine)FDA Link
01/2021
1Phosphoglycerate Mutase (Phosphoglyceromutase)IBA
11/2019
1Epirubicin (Ellence)FDA LinkGeneric
06/2019
1Protein Synthesis InhibitorsIBA
01/2019
1HomoharringtonineIBA
01/2019
1B-Cell Maturation AntigenIBA
01/2019
1Ribonucleotide Reductases (Ribonucleotide Reductase)IBA
04/2018
1Toll-Like Receptors (Toll-Like Receptor)IBA
02/2017
1TNF Receptor-Associated Factor 2 (TRAF2)IBA
02/2017

Therapy/Procedure

23Therapeutics
10/2021 - 05/2002
5Drug Therapy (Chemotherapy)
01/2021 - 05/2005
3Lasers (Laser)
04/2008 - 10/2006
1Salvage Therapy
11/2019